Students will examine the core principles of disease elimination and eradication (E&E) - with a focus on challenges in low-resource settings - and co-develop a draft strategy in a specific country. Students will analyze case studies to better understand lessons learned, challenges faced, and effective interventions needed to achieve disease E&E. The class will provide an introduction to ethical issues in disease E&E, political, social, behavioral, and environmental/climate factors, health system strengthening, the integration of disease E&E programs with existing health systems, and communication and advocacy. Different thinking models (systems, design, strategic & evaluative) will be introduced to help students in their development of interventions to reduce and eventually eliminate disease in a given geography.